QUANTITATIVE STUDIES OF MICROCIRCULATION IN SHOCK.
Progress rept. 1 Mar 68-1 May 69,
CALIFORNIA UNIV SAN DIEGO LA JOLLA
Pagination or Media Count:
The progression of hemorrhagic shock was followed in rabbits, cats and dogs and data was obtained on the pressure distribution throughout the terminal vascular bed in the splanchnic mesentery on variations in colloid osmotic pressure of the blood, on changes in the filtration coefficient as an index of vascular permeability, and the efficacy of blood versus Ringer Lactate as volume replacement measures. Compensatory adjustments attempt to keep capillary pressure constant in the face of a steadily falling plasma c. o. p. With profound hypotension below 40 mm Hg for several hours, the plasma c. o. p. frequently falls below 10 cms H2O normal 20-22 cms H2O. Recovery following either blood replacement or electrolyte infusions need not be associated with a restoration plasma c. o. p. to normal. In fact, r. b. c. sodium lactate mixtures effectively restored flow to capillary bed even after 2 hours of severe hypotension. Subsequent repeated injections of concentrated albumin 25 assisted in restoration of balance between hydrostatic and plasma colloid osmotic pressures. There was no significant increase in permeability coefficient following hemorrhage. Tendency for capillary pressure to rise because of ineffective outflow through venules will give rise to stasis of small veins and interferes with adequate perfusion of tissue during shock. Author
- Anatomy and Physiology
- Medicine and Medical Research