THE EFFECTS OF ATROPINE-OXIME THERAPY ON CHOLINESTERASE ACTIVITY AND THE SURVIVAL OF ANIMALS POISONED WITH DIAZINON
EDGEWOOD ARSENAL ABERDEEN PROVING GROUND MD
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This work was undertaken to determine the effectiveness of atropine- 2-PAMCl treatment of animals poisoned with Diazinon, an organophosphate requiring metabolic activation prior to becoming an inhibitor of Cholinesterase ChE. Inhibited diaphragm ChE in rats poisoned with this organophosphate and treated 24 hours later with 2-PAMCl showed significant reactivation regardless of whether the oxime was administered by the oral or intravenous route. However, 2-PAMCl given with intramuscular atropine to rats intoxicated with Diazinon was significantly more effective by the oral route than when injected intravenously. Our findings suggest that effective treatment of Diazinon intoxication requires the maintenance of a level of oxime high enough to reactivate inhibited ChE during the time in which active inhibitor is formed. This can be more readily achieved when 2-PAMCl is given orally, in conjunction with atropine given intramuscularly, following an initial intravenous dose.
- Medicine and Medical Research