Accession Number:

AD0687081

Title:

RESPONSE OF A SPECIFIC GLUCOCORTICOID-MEDIATED GLYCOPROTEIN (Alpha-2-GP) TO IRRADIATION INJURY,

Descriptive Note:

Corporate Author:

MASON RESEARCH INST WORCESTER MASS DEPT OF IMMUNOLOGY

Personal Author(s):

Report Date:

1968-12-01

Pagination or Media Count:

26.0

Abstract:

Use of a monospecific antiserum reagent permitted detection and quantitation of an alpha-2 glycoprotein alpha-2-GP in the serum of rats subjected to increasing doses of whole-body x-irradiation. It was found that a irradiation injury induced synthesis of this specific glycoprotein macroglobulin, b serum alpha-2-GP levels showed a dose-response relationship, and c cortisol administration following irradiation had an enhancing effect on alpha-2-GP response. Tissue injury resulting from x-irradiation appeared to evoke the same mechanisms of alpha-2-GP response as physical or chemical forms of trauma. Results of a preliminary probe indicated that the apparent dose rate effects may be a reflection of restraint stress with resultant response variations due to endogenous glucocorticoid release. Ancillary studies, designed to use the alpha-2-GP response as an indirect measure of the humoral factor designated HIS responsible for initiation of hepatic synthesis of alpha-2-GP, revealed that serum prepared from normal, nontraumatized animals, in contrast to plasma from the same source, could stimulate hepatic synthesis of alpha-2-GP when administered to normal, nontraumatized animals. The rationale for utilizing HIS release as a biodosimeter for estimating irradiation injury is discussed. Author

Subject Categories:

  • Radiobiology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE