INSULIN-INHIBITORY FACTOR IN HUMAN BLOOD: ROLE IN THE CHARCOAL RADIOIMMUNOASSAY.
Rept. for Jan-Jun 68,
SCHOOL OF AEROSPACE MEDICINE BROOKS AFB TEX
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The insulin-inhibitory factor in human blood was studied. The results of a recovery study with a single-antibody assay the charcoal radioimmunoassay were compared to those with a two-antibody assay to determine whether inhibition occurred between insulin and the first antibody or between the first and the second antibody. The single-antibody assay did not show an insulin-inhibitory factor, but the two-antibody radioimmunoassay did show an inhibitor. The inhibitor must therefore act between the anti-human gamma globulin antibody and the anti-insulin antibody to block the reaction. The exact nature of the inhibitor is as yet unknown. Author
- Medicine and Medical Research