STUDIES ON THE ETIOLOGY AND PREVENTION OF ADVERSE EFFECTS OF INTRAVENOUSLY ADMINISTERED FAT EMULSIONS.
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HARVARD COLL CAMBRIDGE MASS PRESIDENT AND FELLOWS
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The possibility was explored that reactions such as the colloid and overloading syndromes observed in humans receiving intravenous fat emulsions could be duplicated in experimental animals. Rats infused with 20 percent Intralipid 24 hours per day for 10 to 14 days did not show ill effects. In contrast Rhesus monkeys given this emulsion at the same dose 20 m1.kilogram body weight over a period of five hours displayed a decrease in hematocrit and hemoglobin and an elevation in erythrocyte sedimentation rate. These changes could be induced with only one such infusion. Multiple infusions led to anorexia and malaise. When infusions were stopped, eventual return to normal followed. During co-infusions of this emulsion and protein hydrolysate if the latter was begun slightly before the former, acute discomfort, shrieking and in some cases cyanosis were observed almost immediately. If the infusions were discontinued briefly and then restarted, no further reaction occurred. Ten percent Intralipid andor a pure amino acid solution produced none of these adverse effects in monkeys. It is suggested that an aggregation phenomenon involving fat particles and red cells may be at least partially responsible for the colloid and overloading reactions in humans. Author
- Medicine and Medical Research