THE OCCURRENCE OF BLOOD GROUP SUBSTANCES A AND B IN PROPRIETARY GAMMA GLOBULIN OF PLACENTAL ORIGIN.
ARMY MEDICAL RESEARCH LAB FORT KNOX KY
Pagination or Media Count:
Gamma globulin GG preparations derived from pooled placental materials are contaiminated with A and B blood group substances. In vitro assays by a simple quantitative hemagglutination technic show approximately 20 micro gm1 A substance and approximately 165 micro gM1 B substance in most preparations. These materials were administered to 18 male volunteers of groups O, A, and B and shown to be a stimulus to the development of high titer hemolysins, saline agglutinins, and non-neutralizable agglutinins. In addition, titer rises in anti-A andor anti-B saliva agglutinins were seen in the group O recipients. Non-placental serum GG contained no blood group substances by in vitro or in vivo testing. The source of the antigen in placental GG is likely from erthrocytes subjected to freezing and thawing. Thus, a hemolysate derived from washed packed A1 or B cells, subjected to -20C, thawed and passed through 0.22 micro MilliporeR filter, contained significant blood group substance. Placental GG has been advocated for prophylaxis against infectious hepatitis and rubella. Its administration may carry risk by rendering the group O individual a dangerous universal donor, and by increasing the incidence of ABO hemolytic disease in a heterospecific pregnancy of an injected group O mother. Author
- Anatomy and Physiology
- Medicine and Medical Research