Accession Number:

AD0685551

Title:

Effects of Hormonogen Forms of Neurohyprophysial Peptides in Herorrhagic Shock in Dogs,

Descriptive Note:

Corporate Author:

MANITOBA UNIV WINNIPEG DEPT OF PHARMACOLOGY AND THERAPEUTICS

Report Date:

1967-04-10

Pagination or Media Count:

8.0

Abstract:

Hemorrhagic hypotension was induced in chloralosed dogs by the constant-pressure reservoir technique so that the animals were maintained at one-third of resting mean arterial pressure. The animals were injected with 50 microgramkilogram of either N-alpha-triglycyl-8-lysine-vasopressin or N-triglycyl-oxytocin a before the onset of hemorrhage or b after 20 of the external reservoir volume had been taken up. In comparison with untreated controls, the vasopressin analogue resulted in the following hemodynamic changes contraction of the capacitance bed in skeletal muscle and a higher muscle blood flow, a higher cardiac output, a marked and long lasting decrease in splanchnic blood flow, improvement in renal blood flow, absence of metabolic acidosis, and a smaller decrease in oxygen uptake. There was no mortality in the treated animals, as opposed to a 40 mortality in untreated controls. The glycine residues are slowly removed from these extended-chain analogues in vivo, giving rise to pharmacological activity of up to several hours duration following a single dose. This type of drug would, therefore, appear to have advantages in the treatment of clinical hemorrhagic shock. Author

Subject Categories:

  • Anatomy and Physiology
  • Pharmacology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE