Accession Number:

AD0685408

Title:

IMMUNOLOGICAL TOLERANCE TO COXSACKIE B3 VIRUS

Descriptive Note:

Corporate Author:

ARMY BIOLOGICAL LABS FREDERICK MD

Personal Author(s):

Report Date:

1969-02-01

Pagination or Media Count:

10.0

Abstract:

When mice were inoculated with Coxsackie B3 virus at different periods of pregnancy, intrauterine transmission of infection occurred. As a result of inoculation of large virus doses, newborn mice developed the typical infectious process terminating in death of the animals. Some surviving mice showed congenital anomalies. When females were inoculated with reduced virus doses, newborn mice developed immunological tolerance. The study determined maximum and minimum amounts of virus, required for reproduction of this process.

Subject Categories:

  • Anatomy and Physiology
  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE