Accession Number:

AD0685388

Title:

THE EFFECT OF INTERFERON ON THE INHIBITION OF SYNTHESIS OF PROTEINS IN A CULTURE OF CHICK EMBRYO FIBROBLASTS INOCULATED WITH ARBOR VIRUS

Descriptive Note:

Corporate Author:

ARMY BIOLOGICAL LABS FREDERICK MD

Personal Author(s):

Report Date:

1969-02-26

Pagination or Media Count:

7.0

Abstract:

In chick embryo fibroblasts infected with the virus of Venezuelan equine encephalitis the rate of protein synthesis fell to 20-25 of the initial level within 3 hr after infection. In cultures treated with high concentrations of interferon a subsequent infection failed to cause a decline of protein synthesis not only 3-4 but also 24 hr after infection. The cytopathic effect either did not appear or else at an infection density of 500 PFU per cell developed only to a minor degree. Lower concentrations of interferon 32-100 units per ml inhibited multiplication of the virus but did not prevent the decline of protein synthesis and the development of the cytopathic effect.

Subject Categories:

  • Biochemistry
  • Microbiology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE