THE EFFECT OF INTERFERON ON THE INHIBITION OF SYNTHESIS OF PROTEINS IN A CULTURE OF CHICK EMBRYO FIBROBLASTS INOCULATED WITH ARBOR VIRUS
ARMY BIOLOGICAL LABS FREDERICK MD
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In chick embryo fibroblasts infected with the virus of Venezuelan equine encephalitis the rate of protein synthesis fell to 20-25 of the initial level within 3 hr after infection. In cultures treated with high concentrations of interferon a subsequent infection failed to cause a decline of protein synthesis not only 3-4 but also 24 hr after infection. The cytopathic effect either did not appear or else at an infection density of 500 PFU per cell developed only to a minor degree. Lower concentrations of interferon 32-100 units per ml inhibited multiplication of the virus but did not prevent the decline of protein synthesis and the development of the cytopathic effect.