Accession Number:

AD0685121

Title:

THE MECHANISM OF THE STIMULATING EFFECT OF FREUND'S INCOMPLETE ADJUVANT ON ANTIBODY FORMATION,

Descriptive Note:

Corporate Author:

ARMY FOREIGN SCIENCE AND TECHNOLOGY CENTER WASHINGTON D C

Personal Author(s):

Report Date:

1969-02-19

Pagination or Media Count:

15.0

Abstract:

The influence of Freunds incomplete adjuvant on the intensity of antibody formation has been shown to depend both on the characteristics of the antigen, and on its immunizing dose. The greatest stimulating effect on antibody formation upon a single immunization with whooping cough vaccine, is obtained after preliminary injection of Freunds incomplete adjuvant. With typhoid vaccine, the greatest effect was obtained with simultaneous injection of adjuvant and vaccine. Preliminary application of adjuvant does not lead to increased stimulation of antibody formation. Depositing of corpuscular antigens by the adjuvant is not necessary for stimulation of immunogenesis. Author

Subject Categories:

  • Anatomy and Physiology
  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE