Accession Number:

AD0684950

Title:

INVESTIGATION OF PATHOGENESIS AND TREATMENT OF SHOCK.

Descriptive Note:

Annual rept. no. 2 (Final), 1 May 68-30 Apr 69,

Corporate Author:

ROYAL VICTORIA HOSPITAL MONTREAL (QUEBEC)

Personal Author(s):

Report Date:

1969-01-01

Pagination or Media Count:

27.0

Abstract:

Septic shock is frequently characterized by a hyperdynamic state in which one finds a patient with a high central venous pressure, high cardiac index, low peripheral resistance, oliguria, lacticacidosis, hypoxia and respiratory alkalosis. Despite the high cardiac output there is an accumulation of lactate indicating tissue hypoxia. There is frequently a narrow arterio-venous oxygen difference and a low oxygen uptake. These findings are quite contrary to what one would expect. In exercise the cardiac output goes up and the peripheral resistance drops but the arterio-venous difference increases and oxygen uptake increases. A cellular defect or peripheral arterio-venous shunting appear to be the major abnormality in this form of shock and the direction in which further research is likely to proceed. Author

Subject Categories:

  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE