STUDIES ON HUMAN IgD: MOLECULAR WEIGHT AND SEDIMENTATION COEFFICIENT. I. STUDIES ON HUMAN IgM: CHARACTERISTICS OF PRODUCTS OF MILD REDUCTIVE CLEAVAGE. II
Final technical rept. Sep 1967-Nov 1968
LAUSANNE UNIV (SWITZERLAND) INSTITUT DE BIOCHIMIE
Pagination or Media Count:
Immunoglobulin D constitutes a class of human immunoglobulins which is antigenically and functionally distinct from the other classes currently recognized IgG, IgA, IgM and IgE. The antigenic distinctiveness of IgD lies in its heavy polypeptide chains. IgD is present in non-myeloma sera in a relatively small amount but is not sufficiently different in its chromatographic and other characteristics to permit its isolation by physicochemical methods from IgA, IgE and IgG. The most convenient source of IgD for physicochemical studies consists of D-myeloma proteins occurring in serum of rare patients with multiple myeloma. This paper describes the isolation of D-myeloma proteins from two such sera and their sedimentation constants and molecular weights.