Accession Number:

AD0684213

Title:

THE EFFECT OF RADIOPROTECTIVE AGENTS ON ERYTHROPOIESIS IN IRRADIATED MICE,

Descriptive Note:

Corporate Author:

DEFENCE CHEMICAL BIOLOGICAL AND RADIATION ESTABLISHMENT OTTAWA (ONTARIO)

Report Date:

1968-08-24

Pagination or Media Count:

8.0

Abstract:

The radioiron test i.e. 59Fe uptake by blood, spleen, and liver was used to evaluate the degree of protection 1 day after irradiation and effect on recovery 7 days after irradiation of the erythropoietic system when radioprotective agents were administered. In blood, spleen, and liver, AET administered prior to irradiation caused a decreased radiation effect on 59Fe uptake 1 day after irradiation, and a subsequent parallel return with the irradiated nonprotected group to the control value. This indicated that the early recovery by the protected group was probably due to less initial damage. The amount of protection afforded the erythropoietic system by sulfhydryl agents was in good agreement with irradiation survival studies and indicated that a good sylfhydryl radioprotective agent provided good protection, and a poor sulfhydryl radioprotective agent provided poor protection to the erythropoietic system. Thus the radioiron test is a good method to evaluate sulfhydryl compounds as radioprotective agents. Endotoxin demonstrated poor correlation between the early 1 day erythropoietic effect and survival in irradiated mice, but recovery studies 7days showed much better agreement. The biological amine serotonin produced poorer initial protection to the erythropoietic system and slower recovery than AET even though the dose reduction factor of each was comparable. Serotonin must, therefore, protect other systems which then contribute to the eventual recovery of the erythropoietic system, and survival. Author

Subject Categories:

  • Anatomy and Physiology
  • Radiobiology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE