DEMONSTRATION OF BLOOD GROUP SUBSTANCE A BOUND TO PASTEURELLA PESTIS
ARMY MEDICAL RESEARCH LAB FORT KNOX KY
Pagination or Media Count:
Washed P. pestis bacilli prepared from a vaccine containing peptides and peptones of animal origin elicited human anti-A red cell hemolysins in rabbits, whereas similarly treated P. pestis from a vaccine containing peptones and peptides of plant origin did not. Whole vaccine and its various subfractions did not stimulate antibody production for any of the human red cell types when injected into rabbits. Apparently, human blood group A specifically is imparted to P. pestis by blood group contaminating sources present in the media used to cultivate the organism. The evidence shows that, in rabbits, the specific substance expresses itself antigenically only when a concentrated amount is bound to the cell, and that in soluble form it is weakly antigenic or present in subminimal antigenic concentrations.
- Anatomy and Physiology