CEREBRAL CORTEX PRINCIPLES INHIBITING THE PITUITARY-ADRENAL AXIS.
Final scientific rept. 1 Dec 67-30 Nov 68,
MILAN UNIV (ITALY) ISTITUTO DI FARMACOLOGIA E DI TERAPIA
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It was shown that Cerebral Cortex of several mammals contains one or more principles which isare able to inhibit the pituitary-adrenal axis of the rat. The purification of calf cerebral cortices has given yield to a material which is active at the dose of a few micrograms. Cerebral Cortex principles are able a to block the 4.00 p.m. rise in plasma corticosterone in normal rats b to bring back to normal the elevated plasma corticosterone levels which are found in midbrain-sectioned animals and c to counteract the activating effect on the pituitary-adrenal axis of neurogenic stresses. Author
- Anatomy and Physiology