Accession Number:

AD0683039

Title:

THE EFFECT OF PLAGUE MICROBE TOXIN ON THE ACTIVITY OF PYRUVATE-OXYDASE AND LACTATEDEHYDROGENASE IN PLAGUE-SUSCEPTIBLE ANIMALS

Descriptive Note:

Journal article

Corporate Author:

ARMY BIOLOGICAL LABS FREDERICK MD

Personal Author(s):

Report Date:

1967-01-01

Pagination or Media Count:

10.0

Abstract:

Calcium pantothenate, administered subcutaneously and added in tests in vitro, intensifies oxygen consumption by liver homogenates of healthy white mice and reduces consumption of it by liver homogenates of white mice which are contaminated with plague toxin. Thiamine, administered subcutaneously and added in samples, stimulates oxidation of pyruvate by liver homogenates of healthy animals and restores to normal the oxygen consumption of liver homogenates of animals which are contaminated with the toxin of the plague microbe. Plague microbe toxin, added directly to extracts of liver, brain, and serum, does not exert an influence on lactatedehydrogenase activity. Under the influence of plague microbe toxin, administered to animals intraperitoneally, lactatedehydrogenase activity is intensified in blood serum, is suppressed in the brain, and remains without change in the liver.

Subject Categories:

  • Biochemistry
  • Medicine and Medical Research
  • Microbiology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE