Accession Number:

AD0683007

Title:

EFFECT OF CERTAIN CULTURE CONDITIONS ON THE VIRULENCE OF THE PLAGUE MICROBE

Descriptive Note:

Corporate Author:

ARMY BIOLOGICAL LABS FREDERICK MD

Report Date:

1969-01-01

Pagination or Media Count:

3.0

Abstract:

Frequent reseedings of virulent strains of the plague microbe on a thick layer of agar led to a loss of virulence and a weakening of immunogenic properties. Consequently, by means of prolonged storage cultivation of a virulent strain of the plague microbe on a large volume of nutrient medium with infrequent reseedings no more than once a year it is possible to obtain a variant with the properties of vaccine strains for use as a live vaccine.

Subject Categories:

  • Microbiology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE