THE EFFECT OF HIGH CONCENTRATIONS OF CARBON DIOXIDE ON BLOOD SEROTONIN LEVELS IN MAN. CHRONIC HYPERCAPNIA.
Rept. for 17 Nov-7 Dec 67,
SCHOOL OF AEROSPACE MEDICINE BROOKS AFB TEX
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Whole blood serotonin levels in young men were investigated during exposure to a 4 carbon dioxide environment PICO2 29.9 mm. Hg for a 10-day period. No significant change in serotonin levels was found in those men acting as outside controls at ambient 0.03 carbon dioxide, but there was a 34.0 decrease P .01 of serotonin levels in men exposed to 4 carbon dioxide. Exposure to 4 carbon dioxide produced throbbing headaches day 1-2 and nausea day 4-6. Serotonin levels after an initial depression tended to return to control levels during the 4 carbon dioxide exposure period. Observed correlation between carbon dioxide and serotonin suggests that the role of carbon dioxide in control of cerebral circulation may be mediated through serotonin. Author
- Stress Physiology