Accession Number:

AD0680760

Title:

PREREQUISITES FOR CHEMICAL THERMODYNAMIC MODELS OF LIVING SYSTEMS,

Descriptive Note:

Corporate Author:

RAND CORP SANTA MONICA CALIF

Personal Author(s):

Report Date:

1968-11-01

Pagination or Media Count:

137.0

Abstract:

A discussion of the mathematical techniques and physicochemical concepts involved in the construction of certain types of biological models for use in computer simulation. The basic tools employed are a mathematical method and a computer program to calculate the composition of multiphased chemical systems, given the values of certain combinations of state-determining parameters chemical inputs, temperature, pressure. A steady-state approach is used because the scientific basis of thermodynamics is better developed than that of kinetics, the mathematical treatment is easier, and many biological systems are either in or closely approach steady states in their chemical composition. Selection of a physiological function or subsystem to be investigated depends on 1 the availability of technological tools 2 established data 3 whether it is conveniently factorable from a larger system so that it can be studied over a range of conditions when removed from its normal environment 4 no feedback effects as a result of changes in the subsystem. An illustrative model of respiratory gases interacting with an aqueous phase is constructed. Author

Subject Categories:

  • Biochemistry
  • Anatomy and Physiology
  • Thermodynamics

Distribution Statement:

APPROVED FOR PUBLIC RELEASE