Accession Number:

AD0680669

Title:

ACTION OF PYRIDINE-2-ALDOXIME METHOCHLORIDE (PAM) ON NEUROMUSCULAR TRANSMISSION IN VITRO AND IN VIVO,

Descriptive Note:

Corporate Author:

MONTREAL UNIV (QUEBEC) FACULTE DE PHARMACIE

Personal Author(s):

Report Date:

1967-10-18

Pagination or Media Count:

9.0

Abstract:

The action of pyridine-2-aldoxime methochloride PAM was evaluated on nerve-muscle preparations in vitro and in situ. On the isolated diaphragm of the rat, PAM shows a d-tubocurarine-like effect at concentrations higher than 6 mM. No facilitating effects were observed with lower concentrations, even when the acetylcholinesterases were inhibited to an important extent. However, the biphasic actions of PAM could be demonstrated with nerve-muscle preparations of the rat and rabbit in situ lower concentrations produced fasciculations and twitch potentiation whereas a depressing d-tubocurarine-like effect was obtained with higher doses. The decrease in the amplitude of contraction appears to be related to an action at the myoneural junction rather than a direct toxic action on the muscle fibers themselves. Author

Subject Categories:

  • Anatomy and Physiology
  • Pharmacology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE