CONTEMPORARY STATE OF EXPERIMENTAL INVESTIGATIONS ON THE SPECIFIC PROPHYLAXIS OF COCCIDIOIDOMYCOSIS
ARMY BIOLOGICAL LABS FREDERICK MD
Pagination or Media Count:
Live vaccines from virulent, weakly virulent, and avirulent strains of C. immitis created an intense immunity in experimental animals. Here the optimum immunizing doses changed reversely proportional to the degree of virulence of the strain being tested. However, even live vaccines did not exclude as far as possible the appearance of histomorphological or apparent focal changes of weak or moderate severity in the lungs during subsequent respiratory infection or in the organs of the peritoneal cavity - following subsequent intraperitoneal infection with lethal doses of a virulent strain of this fungus.
- Medicine and Medical Research