Accession Number:

AD0680379

Title:

PLAGUE IMMUNOLOGY. 6. BACTERIOLYSIS IN PLAGUE

Descriptive Note:

Corporate Author:

ARMY BIOLOGICAL LABS FREDERICK MD

Report Date:

1968-07-01

Pagination or Media Count:

10.0

Abstract:

Regardless of the many varied attempts to produce bacteriolysis in vitro with plague, the author did not succeed in doing so, and only in one test did they observe any reaction of the bacteriolysins on B. pestis, however this reaction was inconsistent negative results of the other tests. It is possible that here is expressed the lack of constancy in the fixation of the complement under seemingly adequate conditions to which Kolle made reference. The experiments in vivo confirmed the data that in vivo bacteriolysis in plague actually takes place. The injection of complement together with antiplague serum into an animal organism gave inconstant data, which changes in accordance with the method used in infecting the animal and the virulence of the material, but in any case it was possible to note an influence of the complement upon the course of the infection. One cannot consider the negative data received in the staging of the experiments in vitro as final, and think that the failure lies in an imperfection of the present system being used and in a series of as yet unexplored factors which can contribute to the bacteriolysis in vitro in plague.

Subject Categories:

  • Medicine and Medical Research
  • Microbiology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE