PROMISING RESEARCH AREAS-I. A STUDY OF THE BIOLOGICAL EFFECTS OF CHEMICAL SUBSTANCES EMPLOYING THE CONCEPTS AND TECHNIQUES OF PHYSICAL CHEMISTRY.
FEDERATION OF AMERICAN SOCIETIES FOR EXPERIMENTAL BIOLOGY BETHESDA MD
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This report summarizes recent investigations that relate physical changes in macromolecular protein structures to biological functions. It is based on a review by scientists studying protein structure changes induced by van der Waals forces model cell membrane systems that measure the functions of the enzyme permeases the biological applications of nuclear magnetic resonance and electron spin resonance spectra and spin-labeling techniques fluorescence spectra, polarization and decay times, and absorption spectroscopy as indicators of biological events and the significance of molecular geometric changes in a series of biologically active compounds as related to their chemical structure. The topics include the nature of changes produced by chemicals at cell surfaces, enzyme-substrate interactions, novel concepts of charge transport through biological substrates, and their relationship to fine-structure changes in living systems. Author