A GENUS SPECIFIC COMPLEMENT FIXATION ANTIGEN FROM NEISSERIA MENINGITIDIS
NAVAL MEDICAL RESEARCH UNIT NO 4 GREAT LAKES IL
Pagination or Media Count:
A simple method for preparing an N. meningitidis complement fixing antigen is described. Hyperimmune rabbit N. meningitidis antiserum reacted approximately the same with CF antigens made from several N. meningitidis groups or strains. Recruits known to have become infected with N. meningitidis strain Bo during recruit training show equal serological responses to CF antigens made from 5 different N. meningitidis groups or strains. Further, 4 recruits who were admitted to the hospital with clinical meningitis also seroconverted equally to any 1 of 6 different N. meningitidis CF antigens. Increase in CF titer 4-fold or greater to N. meningitidis correlated significantly with acquisition of meningococcus in the nasopharynx as determined by bacterial isolations.
- Medicine and Medical Research