Accession Number:

AD0679675

Title:

RETARDED IMMUNOLOGICAL RECOVERY IN SUBLETHALLY X-IRRADIATED MICE BY ADDITIONAL THYMIC EXPOSURE. REVERSAL WITH INJECTED MARROW CELLS,

Descriptive Note:

Corporate Author:

NAVAL RADIOLOGICAL DEFENSE LAB SAN FRANCISCO CALIF

Personal Author(s):

• Davis,William E. , Jr.
• Cole,Leonard J.

Report Date:

1968-10-24

Pagination or Media Count:

20.0

Abstract:

The role of the intact thymus in recovery of the immune response following a sublethal dose of X radiation was studied. Groups of adult LAF1 mice were exposed to 500 rad of X rays and some of these animals, appropriately lead-shielded, then received an additional 500, 1000, or 2000 rad to the thymic area through a 1.2 cm diameter shield opening. Three criteria of immunological response were employed 1 numbers of Jerne antibody plaque-forming cells PFC in the spleen 2 concentration of antigen-reactive cells ARC 3 rejection time of skin homografts. Author

Descriptors:

• (*IMMUNOLOGY
• RADIATION EFFECTS)
• (*THYMUS
• *RADIATION EFFECTS)
• X RAYS
• MICE
• ANTIGEN ANTIBODY REACTIONS
• SPLEEN
• SKIN(ANATOMY)
• TRANSPLANTATION
• BONE MARROW
• CELLS(BIOLOGY)
• TISSUES(BIOLOGY)
• THERAPY
• RECOVERY

Subject Categories:

• Medicine and Medical Research
• Radiobiology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE