Accession Number:

AD0679581

Title:

A CLINICAL COMPARISON OF SEDATIVE AGENTS IN SURGICAL PREOPERATIVE MEDICATION,

Descriptive Note:

Corporate Author:

NAVAL DENTAL SCHOOL BETHESDA MD

Personal Author(s):

Report Date:

1968-10-23

Pagination or Media Count:

9.0

Abstract:

Despite a number of studies on the efficacy of different drugs, it is still not clear whether hypnotics or tranquilizers can be substituted for barbiturates in the successful sedation of tense or apprehensive dental patients. This report compares, on 92 patients, the relative effectiveness of 750 mg. of ethinamate a hypnotic, 100 mg. of hydroxyzine an ataractic, 100 mg. of pentobarbital a barbiturate, and a placebo. The study was limited to patients whose apprehensiveness was substantiated by their own admission and by objective evaluation. Decreased apprehension was evaluated by the same criteria. After 30 to 60 minutes, pentobarbital had reduced apprehension in 33 percent of the patients, which was of marginal statistical significance as compared with a reduction in only 9 percent of those receiving placebos. Neither ethinamate nor hydroxyzine produced a reduction significantly different from that of the placebo. It was concluded that short-acting barbiturates remain the preoperative sedatives of choice. Author

Subject Categories:

  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE