RECEPTORS CONCERNED IN THE REGULATION OF THE BLOOD TITER OF VASOPRESSIN.
Progress rept. 10 May 67-1 Jul 68,
CASE WESTERN RESERVE UNIV CLEVELAND OHIO DEPT OF PHYSIOLOGY
Pagination or Media Count:
The work of this laboratory is concerned with the study of the secretion of the two hormones stored in the posterior pituitary gland, vasopressin and oxytocin. Peripheral receptors, located in the cardiovascular system, are required for the increased release of vasopressin which occurs in response to hemorrhage. These receptors are left atrial stretch receptors, carotid sinus baroreceptors, and, presumably, aortic arch baroreceptors. The atrial receptors may play a primary role in the reflex release of vasopressin following moderate hemorrhage. When the atrial receptors are denervated, however, the carotid sinus receptors can function in this reflex with only moderate impairment in the magnitude of the response. In adrenal insufficiency in the dog, the plasma ADH concentration is elevated. This can be prevented, for a period of three days, at least, by supplementation with salt. In the non-pregnant sheep, distention of the vagina results in an increased release of oxytocin. This response is potentiated by pre-treatment with estrogen. In the pregnant sheep, vaginal distention results in a fall in the plasma oxytocin concentration. These findings suggest the possibility of an interaction between the female sex hormones and the mechanism controlling the release of oxytocin. Author
- Anatomy and Physiology