Accession Number:

AD0678905

Title:

A STUDY OF THE INTENSITY OF CROSS AND TYPE IMMUNITY IN BRUCELLOSIS

Descriptive Note:

Corporate Author:

ARMY BIOLOGICAL LABS FREDERICK MD

Personal Author(s):

Report Date:

1968-07-01

Pagination or Media Count:

12.0

Abstract:

Investigations which were made with guinea pigs to test the intensity of type and cross immunity produced by live vaccines of the type Br. abortus No 104-M, No 19-BA and melitensis Elbergs strain Rev. 1 with respect to infection by highly virulent cultures of Br. melitensis No 565, Br. suis No 1330, and Br. abortus 10L do not provide a basis for indicating that cross immunity is weaker than type immunity in the case of brucellosis. In a comparative study of the immunogenicity of vaccine strains of the cattle and sheep types under conditions of testing the intensity of immunity by various doses of highly virulent cultures of Br. melitensis, suis and abortus, it was established that strain Rev 1 has a high immunogenicity which is not inferior to that of Br. abortus No 104-M. Strain Br. abortus No 104-M upon subcutaneous vaccination produced immunity in guinea pigs to cultures of Br. abortus, suis, and melitensis which were more intense than was the case with strain Br. abortus No 19-BA.

Subject Categories:

  • Medicine and Medical Research
  • Microbiology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE