THE BIOLOGICAL CHARACTERISTICS OF INAGGLUTINABLE CULTURES OF BRUCELLA MELITENSIS
ARMY BIOLOGICAL LABS FREDERICK MD
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The inagglutinable cultures of Br. melitensis were studied that were typical with respect to their morphological and cultural aspects and also with respect to their ability to reduce aniline dyes. A distinctive feature was the presence of positive signs of dissociation and the loss of the ability to be agglutinated by a specific antibrucellosis serum. With respect to these aspects they were identical to the cultures described by Drozhevkina as V-cultures. The inagglutinable Brucella cultures had lowered virulence in various degrees in comparison with the agglutinable cultures. The somewhat large residual virulence of some of the inagglutinable strains No 512, 705, 65 could be explained by the presence in the population of a small percentage of agglutinable undissociated species, the predominant settlement of which in the organism of the guinea pigs was the basis for the development of infection.