HYPOTHALAMIC SECRETORY FACTOR FOR ADRENOCORTICOTROPIC HORMONE.
Final technical rept. 16 Aug 66-15 Aug 67,
NORTH CAROLINA UNIV CHAPEL HILL DEPT OF PHARMACOLOGY
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The following subjects were investigated during the grant period, 1966-67. 1 Further development of the biological assay method for the hypothalamic secretory factor for ACTH, also known as corticotropin releasing factor CRF. 2 Further investigation of methods for purifying CRF from bovine and ovine hypothalamic tissue. 3 Study of adrenal cortical steroid metabolites in monkey urine, preliminary to investigation of effects of CRF in monkeys. 4 Study of adrenal cortical steroid metabolites in human urine, preliminary to investigation of effects of CRF in man. No clinical studies involving administration of CRF to man were conducted. Author