MECHANISM OF THE PASTEUR EFFECT
ARMY BIOLOGICAL LABS FREDERICK MD
Pagination or Media Count:
When nucleated pigeon erythrocytes are treated with nitrite or hydrogen peroxide the Pasteur effect is lost or greatly diminished the respiration remains unchanged, but aerobic lactic acid formation sets in, attaining the level of anaerobic glycolysis. The effect does not depend on methemoglobin formation in nitrited cells incubation with excess lactate brings about a complete reduction of methemoglobin, but the inhibition of the Pasteur effect persists. The suppression of the Pasteur effect produced by H2O2 was found to be reversible and disappears on subsequent treatment with sodium hydrosulphite, though this has no effect on nitrited cells.