EFFECT OF METHAQUALONE ON BEHAVIOR OF THE CHIMPANZEE.
AEROMEDICAL RESEARCH LAB (6571ST) HOLLOMAN AFB N MEX
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A complex operant performance program was used to assess the effect of methaqualone on the behavior of four chimpanzees. The performance program consisted of a Sidman avoidance schedule with concurrent discrete avoidance to both visual and auditory signals. One subject received 5.0 mg.kg. methaqualone and three subjects received 10.0 mg.kg. methaqualone per injection. One subject showed no effect of a single injection of 10.0 mg.kg. but was affected by a second injection given after 48 hours. The other three subjects were exposed to methaqualone only once. All injections were administered i.v. into a vein in the antecubital fossa. With the exception of the one injection that had no visible effect, the subjects displayed unconsciousness for 15 to 30 minutes immediately following injection. Impairment of operant behavior was evident for from 30 minutes to 6 hours following injection. One subject exhibited significant behavioral impairment on the day after an injection of 10.0 mg.kg. methaqualone. Author