Accession Number:

AD0677924

Title:

ANALYSIS OF THE RADIATION-INDUCED LOSS OF TESTES WEIGHT IN TERMS OF STEM CELL SURVIVAL,

Descriptive Note:

Corporate Author:

NAVAL RADIOLOGICAL DEFENSE LAB SAN FRANCISCO CALIF

Personal Author(s):

Report Date:

1968-09-18

Pagination or Media Count:

22.0

Abstract:

The proportion of radiation-insensitive tissue in the testes of the C57L mouse was determined to be 36.9 of the normal nonirradiated testes weight. The weights of testes of these mice at 28 days after various doses of irradiation were analyzed by subtracting out the radiation-insensitive weight and calculating the surviving fraction SSo of radiation-sensitive weight. The logarithm of SSo could be fitted linearly to the radiation dose, indicating an exponential tissue-loss process with a D37 for 250 KVp X-rays of 78.9 rad. The D37 for testes weight loss from sission-neutron irradiation was 21.0 rad, indicating a relative biological effectiveness ratio R.B.E. for fission neutrons of 3.75. Treatment of mice with AET 2-aminoethylisothiouronium bromide hydrobromide 15 minutes before irradiation with X-rays increased the D37 to 119.6 rad, indicating a protection ratio of 1.5 for AET. Treatment of mice with Piromen pseudomonas polysaccharide 24 hours before irradiation had no effect on the D37 for testes weight loss. Irradiation with X-rays at 2.8 Rmin gave the same D37 for testes weight loss as irradiation at 14 Rmin. The data indicate that loss of weight of the testes after irradiation reflects the survival curve of the germinal cell layer of the testes. Author

Subject Categories:

  • Radiobiology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE