HYDRATION OF MACROMOLECULES IN THE NATIVE AND DENATURED STATES
ARMY BIOLOGICAL LABS FREDERICK MD
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The question of the reciprocal influence of macromolecules and the water layers adjacent to them is examined. The Kauzmann and Klotz models are compared. Experimental calorimetric findings on macromolecule hydration are cited. The denaturation change of hydration is studied. It is demonstrated that hydration of denatured macromolecules is greater than hydration of native molecules, which speaks in favor of Kauzmanns model.