MOLECULAR MECHANISMS OF ALKYLATION OF A BIOLOGICAL SYSTEM
ARMY BIOLOGICAL LABS FREDERICK MD
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Among chemical mutagens the group of alkylating compounds occupies a singular position both in intensity of action on the mutagenesis of various organisms, as well as in diversity of structure of functional centers. Investigation of the molecular mechanism of action of mutagens has a direct bearing on a most crucial problem in genetics -- directed hereditary variability. The report examines the fundamentals of the process underlying formation of mutations from the chemical vantage point.