THE EFFECT OF BACTERIAL TOXINS ON TISSUE CULTURE
ARMY BIOLOGICAL LABS FREDERICK MD
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Bacterial toxins excepting tetanic caused various degrees of degenerative changes in the cells of a tissue culture of human embryos. The dynamics and characteristics of these changes seemed to be heterogeneous, when the effects of exotoxins and endotoxins were compared. Specific and selective effects of bacterial toxins on the cells of various kinds of tissue culture were noted. With the combined action of exotoxins on a culture of human embryo fibroblasts, the cytotoxic effect was intensified, and pathologic changes in the cells occurred before those taking place in the control cells. The combined effect of endotoxins of dysenteric Flexner and abdominal-typhous microbes did not intensify degeneration of the tissue culture of human embryo fibroblasts.