MECHANISM OF THE EFFECT OF INTERFERON ON THE MULTIPLICATION OF VACCINIA VIRUS AND CELL METABOLISM
ARMY BIOLOGICAL LABS FREDERICK MD
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Interferon suppressed multiplication of the vaccinia virus in a chick fibroblast tissue culture. Treatment of chick fibroblast cells with interferon before their infection with vaccinia virus suppressed the synthesis of virus DNA and, to a lesser extent, that of virus protein. Interferon altered cell metabolism, suppressing the incorporation of adenine-C14 in all the fractions studied, and particularly in the protein fraction. In the cells infected with vaccinia virus but not treated with interferon an increase in isotope capture was noted in the DNA fraction after three hours, and in all the fractions studied after 24 hours.