Accession Number:

AD0677598

Title:

ACUTE MORTALITY AND RECOVERY STUDIES IN BURROS IRRADIATED WITH 1Mvp X-RAYS,

Descriptive Note:

Corporate Author:

NAVAL RADIOLOGICAL DEFENSE LAB SAN FRANCISCO CALIF

Report Date:

1968-09-05

Pagination or Media Count:

31.0

Abstract:

With 1 Mvp X-rays, the acute LD5030 midline air exposure of adult female burros was determined to be 369 R the acute LD5060 was determined to be 344 R. The split-dose technique, which consists of conditioning animals with a sublethal exposure and redetermining the LD50 at various times thereafter, was used to determine the recovery pattern after an exposure to 250 R. By this method, the burro appeared to have recovered from 48 of the initial injury at 60 days and from 85 at 90 days. A bimodal death pattern was seen in the normal burros, with peaks at 2.4 and 24.2 days. The early death response was dose related. When the LD50 for 1 Mvp X-rays was compared with earlier reported LD50s, it was found that there is an apparent exposure-rate-effectiveness relationship for the burro. The pattern of recovery at 60 and 90 days was found to closely parallel the return of white blood cells to normal values. The slow recovery has been suggested to be a reflection of the small numbers of circulating lymphocytes that were present after the radiation exposures. Author

Subject Categories:

  • Radiobiology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE