GROWTH-INHIBITORY ACTIVITIES OF SOME 1,4-NAPHTHOQUINONES AND RELATED COMPOUNDS ON STAPHYLOCOCCUS AUREUS AND ESCHERICHIA COLI.
DEFENCE RESEARCH ESTABLISHMENT SUFFIELD RALSTON (ALBERTA)
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Growth-inhibitory activities of some or all of 98 1,4-naphthoquinones and 16 related compounds on Escherichia coli and two strains of Staphylococcus aureus were determined alone or in combination. These values, when plotted against their polarographic half-wave potentials and those of their C2-n-butylthio analogs support the hypothesis that these compounds, or the products resulting from their reaction with a protein nucleophile, function by short-circuiting one or other of the quinones present in the electron-transport chain. Author