Accession Number:

AD0677126

Title:

GROWTH-INHIBITORY ACTIVITIES OF SOME 1,4-NAPHTHOQUINONES AND RELATED COMPOUNDS ON STAPHYLOCOCCUS AUREUS AND ESCHERICHIA COLI.

Descriptive Note:

Technical paper,

Corporate Author:

DEFENCE RESEARCH ESTABLISHMENT SUFFIELD RALSTON (ALBERTA)

Report Date:

1967-07-20

Pagination or Media Count:

7.0

Abstract:

Growth-inhibitory activities of some or all of 98 1,4-naphthoquinones and 16 related compounds on Escherichia coli and two strains of Staphylococcus aureus were determined alone or in combination. These values, when plotted against their polarographic half-wave potentials and those of their C2-n-butylthio analogs support the hypothesis that these compounds, or the products resulting from their reaction with a protein nucleophile, function by short-circuiting one or other of the quinones present in the electron-transport chain. Author

Subject Categories:

  • Microbiology
  • Pharmacology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE