Accession Number:

AD0676146

Title:

GLUCOSE TOLERANCE IN DOGS EXPOSED TO ALTITUDE AND DRUG ADMINISTRATION: AMPHETAMINE.

Descriptive Note:

Rept. for Sep-Oct 67,

Corporate Author:

SCHOOL OF AEROSPACE MEDICINE BROOKS AFB TEX

Personal Author(s):

Report Date:

1968-06-01

Pagination or Media Count:

11.0

Abstract:

This study was initiated to determine the effect of altitude and drug administration on glucose tolerance at altitude. Dogs were exposed to a simulated altitude of 27,000 ft. and the rate of disappearance of intravenously injected glucose 0.5 gm.kg. was compared with similar tests at ground level. All dogs were maintained on the same PO2 in the inspired air 152 mm. Hg PO2. In addition, amphetamine 1 mg.kg. I.V. was administered to the dogs under both atmospheric conditions. A significant increase was seen in the K-value of the nondrug dogs exposed to simulated altitude P less than .01. Also, a significant increase in the K-value was noted in the dogs treated with amphetamine at ground level as compared with ground-level controls P less than .01. The K-value of dogs exposed to altitude and administered amphetamine was significantly raised P less than .01 as compared with both ground-level and altitude nondrug conditions. Author

Subject Categories:

  • Stress Physiology
  • Pharmacology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE