Accession Number:

AD0673947

Title:

MONKEYS AS HOSTS OF HUMAN MALARIA.

Descriptive Note:

Annual rept. 1 May 67-30 Apr 68,

Corporate Author:

GORGAS MEMORIAL LAB BALBOA HEIGHTS CANAL ZONE

Report Date:

1968-06-01

Pagination or Media Count:

21.0

Abstract:

The purpose of this work is to determine the feasibility of growing and maintaining human malaria in monkeys, the use of this model for the study of host parasites relationships, for the detection of drug resistant strains of malaria, and for trials of promising new anti-malarial drugs. Previously it was shown that Plasmodium vivax could be grown in Aotus trivirgatus night monkey and Saguinus geoffroyi marmosets. During the past year, this malaria has grown well also in the spider monkeys Ateles fusciceps and A. geoffroyi and less well in Cebus capucinus white face monkey. One P. vivax strain, the Achiote, went through 36 serial passages and another, the Santa Rosa, through 26 passages during the year. The continuous passages developed information on some of the characteristics of these induced infections. Progress was made toward standardization of the infections. For the first time, mosquito transmission of P. vivax from monkey to monkey was accomplished. Author

Subject Categories:

  • Anatomy and Physiology
  • Microbiology
  • Pharmacology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE