Accession Number:

AD0673868

Title:

A STUDY OF THE COMPLETENESS OF PHAGOCYTIC REACTION DURING THE PROCESS OF PLAGUE IMMUNIZATION,

Descriptive Note:

Corporate Author:

ARMY BIOLOGICAL LABS FREDERICK MD

Report Date:

1965-09-21

Pagination or Media Count:

11.0

Abstract:

The phagocytic number for spleen and liver RES reticuloendothelial system cells declines significantly in the process of immunogenesis with live P. pestis vaccine on the 21st to 25th day it is five to ten-fold less than in the case of intact animals. The phagocytic number for hemoleukocytes in the immunogenesis process increases on the 11th post-immunization day, then drops to initial level. The phagocytic number for subcutaneous-tissue cells during the immunization process drops 1.5 to two-fold as of the 25th day after vaccination. Completeness of phagocytic reaction in experiments with hemoleukocytes, spleen cells, liver cells and subcutaneous-tissue cells declines greatly on the 6th to 12th post-vaccinative day since P. pestis actively propagates inside the cells during this period. In subsequent periods the completeness of phagocytic reaction rises and on the 21st post-vaccinative day in most experiments phagocytosis becomes complete 56 plus or minus 9 for hemoleukocytes, 33 plus or minus 6 for subcutaneous-tissue cells, 36 plus or minus 8.5 for spleen cells. In liver cells completeness of phagocytic reaction was not observed.

Subject Categories:

  • Medicine and Medical Research
  • Microbiology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE