Accession Number:

AD0673865

Title:

USE OF THE ANTIBODY NEUTRALIZATION TEST FOR STUDYING THE BODIES OF RODENTS KILLED BY PLAGUE,

Descriptive Note:

Corporate Author:

ARMY BIOLOGICAL LABS FREDERICK MD

Report Date:

1965-09-17

Pagination or Media Count:

8.0

Abstract:

With the use of the antibody neutralization test it is possible to study the decomposed bodies of plague-infected animals. Up to 18 days the observation period after the death of the animal, when the carcass is kept at room temperature there appeared to be no regular reduction in antibody activity in the antibody neutralization test ANT. By using bacteriological or biological methods the plague pathogen was isolated only during the first seven days after the death of the animal. In treating the tissue suspension with Formalin, heating, and filtering the non-specific clumping of erythrocytes was kept to a minimum in the antibody neutralization test, while the activity of the suspension did not change substantially. In analyzing suspensions of the various types of animals perished from plague 132 carcasses in the antibody neutralization test, it was established that the activity of organ suspensions of guinea pigs and white rats was somewhat lower than that of white mice, susliks, and Meriones meridianus gerbils from the left bank of the river. The spleen suspension from the above-mentioned animals often showed the greatest activity. Dessicated soft tissue and bone of the animals carcass can be analyzed with the antibody neutralization test.

Subject Categories:

  • Microbiology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE