Accession Number:

AD0673864

Title:

INTRACUTANEOUS ALLERGIC REACTION WITH THERMOSTABLE EXTRACTS OF PASTEURELLA PESTIS

Descriptive Note:

Corporate Author:

ARMY BIOLOGICAL LABS FREDERICK MD

Personal Author(s):

Report Date:

1965-09-21

Pagination or Media Count:

11.0

Abstract:

Thermostable antigens intracutaneously injected are capable of reflecting allergic reorganization of the organism in immune, as well as immunized guinea pigs which in this event exhibit positive local inflammatory reaction. Non-immunized guinea pigs react negatively. The intracutaneous test, staged on 25 volunteers, yielded positive results for all persons systematically vaccinated here less pronounced positive reactions were observed for persons who had received one or two vaccinations. A negative reaction was observed in the case of persons who had not been vaccinated at all, and a slight reaction in persons vaccinated long ago. Filtering the allergen through a candle and drying it stabilized the preparation with almost no reduction in its activity. No connection was found between the virulence of P. pestis and its allergenic properties.

Subject Categories:

  • Medicine and Medical Research
  • Microbiology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE