THE SPREAD FACTOR OF THE PLAGUE BACILLUS. COMMUNICATION II. DISCOVERY OF HYALURONIDASE IN THE PLAGUE BACILLUS
ARMY BIOLOGICAL LABS FREDERICK MD
Pagination or Media Count:
The experiments were performed for the purpose of determining whether active plague preparations which develop the spread phenomenon in vivo contain the enzyme hyaluronidase. The detection of hyaluronidase in vitro is based upon the fact that because of its action hyaluronic acid loses its ability to form a clot in an acid medium, its viscosity is decreased depolymerization and it is hydrolytically decomposed into glucuronic acid and glucosamine.