Accession Number:

AD0673303

Title:

VIROLOGICAL STUDY OF LABORATORY INFECTIONS WITH VENEZUELAN EQUINE ENCEPHALOMYELITIS

Descriptive Note:

Corporate Author:

ARMY BIOLOGICAL LABS FREDERICK MD

Report Date:

1968-07-01

Pagination or Media Count:

9.0

Abstract:

Virological and serological examinations were conducted on 63 people, the patients with Venezuelan equine encephalomyelitis, the persons who had been in contact with the patients, and those having worked with the indicated virus. Thirty-six persons were examined by serological and virological methods, and 27 were examined by serological methods alone. Isolation of the virus was conducted on white mice and chick embryos. From the 36 persons 87 different samples of blood, mouth washings, urine and feces were examined for the virus. The virus was detected in eight patients on the 2-6th day of the disease. Three strains were isolated from the blood, and six strains from the mouth washings. In the neutralization test 99 blood sera, taken from 63 persons, were examined. The blood sera from the convalescents were investigated dynamically 2-3 times. Antibodies to the Venezuelan equine encephalomyelitis virus were observed in twenty persons, with which all of them endured the disease. There were no cases observed of an asymptomatic course of the infection in those persons having had contact with the patients, or in those having worked with the virus. Antibodies were detected in the convalescents in a sufficiently high titer by the 10-12th day of the illness. As a result of complex virological and serological investigations a diagnosis of Venezuelan encephalitis was confirmed in twenty persons. Author

Subject Categories:

  • Microbiology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE