THE IMPAIRMENT OF GLUCOGENESIS BY GRAM NEGATIVE INFECTION
BROOKE ARMY MEDICAL CENTER FORT SAM HOUSTON TX ARMY SURGICAL RESEARCH UNIT
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In vitro studies of gluconeogenesis in rat liver tissue have been carried out. The rates of glucogenesis of liver slices from rats suffering from a Pseudomonas aeruginosa infection and rats injected with a lethal dose of Escherichia coli endotoxin have been measured. The liver content of certain key glucogenic enzymes was also measured in these animals. The specific enzymes studied were glucose-6-phosphatase, fructose-1,6-diphosphatase and phosphoenol- pyruvate carboxykinase. The overall rate of glucogenesis in liver slices was shown to be impaired by infection and endotoxemia. The liver activity of glucose-6-phosphatase was significantly lower in the infected and endotoxic animals than in controls. The other enzymes studied appeared unaffected.
- Anatomy and Physiology