Accession Number:

AD0673252

Title:

THE IMPAIRMENT OF GLUCOGENESIS BY GRAM NEGATIVE INFECTION

Descriptive Note:

Corporate Author:

BROOKE ARMY MEDICAL CENTER FORT SAM HOUSTON TX ARMY SURGICAL RESEARCH UNIT

Report Date:

1968-01-01

Pagination or Media Count:

7.0

Abstract:

In vitro studies of gluconeogenesis in rat liver tissue have been carried out. The rates of glucogenesis of liver slices from rats suffering from a Pseudomonas aeruginosa infection and rats injected with a lethal dose of Escherichia coli endotoxin have been measured. The liver content of certain key glucogenic enzymes was also measured in these animals. The specific enzymes studied were glucose-6-phosphatase, fructose-1,6-diphosphatase and phosphoenol- pyruvate carboxykinase. The overall rate of glucogenesis in liver slices was shown to be impaired by infection and endotoxemia. The liver activity of glucose-6-phosphatase was significantly lower in the infected and endotoxic animals than in controls. The other enzymes studied appeared unaffected.

Subject Categories:

  • Anatomy and Physiology
  • Microbiology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE