Accession Number:

AD0673210

Title:

THE UTILIZATION OF TISSUE CULTURES FOR PRODUCTION OF VACCINES AGAINST VENEZUELAN AND AMERICAN WESTERN EQUINE ENCEPHALOMYELITIS VIRUSES

Descriptive Note:

Corporate Author:

ARMY BIOLOGICAL LABS FREDERICK MD

Personal Author(s):

Report Date:

1968-07-01

Pagination or Media Count:

14.0

Abstract:

The American western and Venezuelan equine encephalomyelitis viruses accumulate in cultural fluid in high titers with the use of a protein-free medium, however, the viral titer soon drops sharply. It follows, therefore, to use a cultural fluid that has been collected within 24 hours after inoculation for the production of vaccine. The cultural formalinized vaccines against the American western and Venezuelan equine encephalomyelitis viruses cause the appearance of virus-neutralizing antibodies in the sera of vaccinated animals and protect mice from the disease when they are given an intraperitoneal injection of up to 1,000,000 LD50 of the virus, thus proving themselves to be highly immunogenic preparations. Author

Subject Categories:

  • Microbiology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE