SOME PROBLEMS OF TISSUE HETEROTRANSPLANTATION
ARMY BIOLOGICAL LABS FREDERICK MD
Pagination or Media Count:
Complicated biological processes develop in both the host organism and in the transplant in any free transplantation of organs and tissues. In the transplant, there occur unavoidable degenerative changes that are related to the disruption of innervation and blood supply. These changes are then replaced by the regenerative processes in autoplasty, and by a displacement of the transplant by the hosts tissues in homoplasty and heteroplasty. The reactive changes in the surrounding tissues contribute to the adaptation of the transplant. In homo- and heterotransplantations, the reactions of the tissues and of the entire organism consist of a generation of antibodies in response to the tissular antigens of the transplant, which leads, in the final analysis, to the disengagement or resorption of the latter. Inasmuch as the fate of the transplants depends on immune reactions, the question of tissue compatibility has an immunological basis and represents a general biological problem.
- Medicine and Medical Research