Accession Number:

AD0673155

Title:

SOME PROBLEMS OF TISSUE HETEROTRANSPLANTATION

Descriptive Note:

Corporate Author:

ARMY BIOLOGICAL LABS FREDERICK MD

Report Date:

1968-07-01

Pagination or Media Count:

8.0

Abstract:

Complicated biological processes develop in both the host organism and in the transplant in any free transplantation of organs and tissues. In the transplant, there occur unavoidable degenerative changes that are related to the disruption of innervation and blood supply. These changes are then replaced by the regenerative processes in autoplasty, and by a displacement of the transplant by the hosts tissues in homoplasty and heteroplasty. The reactive changes in the surrounding tissues contribute to the adaptation of the transplant. In homo- and heterotransplantations, the reactions of the tissues and of the entire organism consist of a generation of antibodies in response to the tissular antigens of the transplant, which leads, in the final analysis, to the disengagement or resorption of the latter. Inasmuch as the fate of the transplants depends on immune reactions, the question of tissue compatibility has an immunological basis and represents a general biological problem.

Subject Categories:

  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE