Accession Number:

AD0673047

Title:

THE EFFECT OF PHYSICAL AND CHEMICAL RESTRAINT ON SELECTED RESPIRATORY PARAMETERS OF MACACA MULATTA

Descriptive Note:

Corporate Author:

FORT DETRICK FREDERICK MD

Personal Author(s):

Report Date:

1968-01-01

Pagination or Media Count:

4.0

Abstract:

A comparison of the respiration of Macaca mulatta restrained with strait jackets or injected intramuscularly with 1 mgkg of phencyclidine hydrochloride revealed that the minute volume of the strait-jacketed animals was about 3 times that of relatively unrestrained animals when measurements were made 10, 20, and 30 minutes after treatment. The values obtained from the drug- treated animals were about 60 of those predicted by Guyton 3, and those obtained from strait-jacketed monkeys were about 200 of Guytons predicted values. These differences were found to be statistically significant in every case. The 2 treatments also produced significantly different respiration rates drug-treated monkeys about 67 of the strait-jacketed animals, heart rates drug-treated rate about 84 of the jacketed monkeys, and tidal volumes drug- treated about 52 of the jacketed animals volumes.

Subject Categories:

  • Anatomy and Physiology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE