THE EFFECT OF PHYSICAL AND CHEMICAL RESTRAINT ON SELECTED RESPIRATORY PARAMETERS OF MACACA MULATTA
FORT DETRICK FREDERICK MD
Pagination or Media Count:
A comparison of the respiration of Macaca mulatta restrained with strait jackets or injected intramuscularly with 1 mgkg of phencyclidine hydrochloride revealed that the minute volume of the strait-jacketed animals was about 3 times that of relatively unrestrained animals when measurements were made 10, 20, and 30 minutes after treatment. The values obtained from the drug- treated animals were about 60 of those predicted by Guyton 3, and those obtained from strait-jacketed monkeys were about 200 of Guytons predicted values. These differences were found to be statistically significant in every case. The 2 treatments also produced significantly different respiration rates drug-treated monkeys about 67 of the strait-jacketed animals, heart rates drug-treated rate about 84 of the jacketed monkeys, and tidal volumes drug- treated about 52 of the jacketed animals volumes.
- Anatomy and Physiology